Determination of Thiabendazole and 5-Hydroxythiabendazole in Livestock Foods by HPLC-UV

[Determination of benzimidazole anthelmintics in livestock foods by HPLC].

A simple and rapid liquid chromatographic method was developed for the simultaneous determination of twelve benzimidazole anthelmintics in livestock foods using reversed-phase high-performance liquid chromatography with photodiode array detection (PDA). A sample was homogenized with acetonitrile and n-hexane, and centrifuged. The acetonitrile phase was isolated and evaporated. The residue was d...

Dmd #8094 1 in Vitro Metabolic Activation of Thiabendazole via 5- Hydroxythiabendazole: Identification of a Glutathione Conjugate of 5- Hydroxythiabendazole

In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.

Thiabendazole (TBZ) is a broad-spectrum antihelmintic used for treatment of parasitic infections in animals and humans and as an agricultural fungicide for postharvest treatment of fruits and vegetables. It is teratogenic and nephrotoxic in mice, and cases of hepatotoxicity have been observed in humans. Recent reports have demonstrated a correlation between 5-hydroxythiabendazole (5-OHTBZ) form...

Determination of Phylloquinone and Menaquinones in Foods by Hplc

High-performance liquid chromatographic (HPLC) methods for determining vitamin K contents in oils and margarines, vegetables, fruits and berries, cereals and animal products were developed. These methods were applied to analysing phylloquinone and menaquinone in a total of 87 food items. In addition, the 2 ́,3 ́-dihydrovitamin K1 contents of a few margarines and hydrogenated oils were determined,...

Simultaneous Chloramphenicol and Florfenicol Determination by A Validated DLLME-HPLC-UV Method in Pasteurized Milk

The antibiotic residues in milk are a well-known serious problem and pose several health hazards to consumers. We have described a simple, rapid, and inexpensive DLLME-HPLC/UV technique for the extraction of chloramphenicol and florfenicol residues in milk samples. Under the optimum conditions, linearity of the method was observed over the range 0.02-0.85 µg/L with correlation coefficients > 0....